Addiction. A man's hand with a cigarette and a woman's hand holding an e-cigarette.CRoFT scientists conducted a clinical trial for which they recruited 18 smokers. Smokers were asked to puff on an e-cigarette with the fixed nicotine content but containing six different flavors.

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Researchers collected multiple blood samples and measured how smokers puffed on an e-cigarette with different flavors. They found that when smokers puff on fruit-flavored e-cigarette, they took longer and deeper puffs compared to tobacco cigarettes. Vaping different flavors resulted in varying levels of plasma nicotine.

Interestingly, when smokers used a fruit-flavored e-cigarette (cherry), they inhaled higher doses of nicotine compared to other flavors. This study suggests that flavors in e-cigarettes may change the way smokers puff on the product, and this may result in inhalation of higher nicotine doses.