CRoFT scientists conducted a clinical trial for which they recruited 18 smokers. Smokers were asked to puff on an e-cigarette with the fixed nicotine content but containing six different flavors.
Read the publication abstract
Researchers collected multiple blood samples and measured how smokers puffed on an e-cigarette with different flavors. They found that when smokers puff on fruit-flavored e-cigarette, they took longer and deeper puffs compared to tobacco cigarettes. Vaping different flavors resulted in varying levels of plasma nicotine.
Interestingly, when smokers used a fruit-flavored e-cigarette (cherry), they inhaled higher doses of nicotine compared to other flavors. This study suggests that flavors in e-cigarettes may change the way smokers puff on the product, and this may result in inhalation of higher nicotine doses.